Publications | Schlaepfer Lab Web

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PUBLICATIONS

2019

CJ Díaz-Osterman, D Ozmadenci, EG Kleinschmidt, KN Taylor, AM Barrie, S Jiang, LM Bean, FJ Sulzmaier, C Jean, I Tancioni, K Anderson, S Uryu, EA Cordasco, J Li, XL Chen, G Fu, M Ojalill, P Rappu, J Heino, AM Mark, G Xu, KM Fisch, VN Kolev, DT Weaver, JA Pachter, B Győrffy, MT McHale, DC Connolly, A Molinolo, DG Stupack and DD Schlaepfer (2019). FAK activity sustains intrinsic and acquired ovarian cancer resistance to platinum chemotherapy. eLife 8:e47327 DOI: 10.7554/eLife.47327. PMID: 31478830

EG Kleinschmidt, NLG Miller, D Ozmadenci, I Tancioni, CJ Díaz-Osterman, AB Barrie, KN Taylor, A Ye, S Jiang, DC Connolly, DG Stupack and DD Schlaepfer (2019). Rgnef promotes ovarian tumor progression and confers protection from oxidative stress. Oncogene 38(36):6323-6337. PMID: 31308489

K Jeong, JH Kim, JM Murphy, H Park, SJ Kim, Y Rodriguez, H Kong, C Choi, J-L Guan, JM Taylor, TM Lincoln, WT Gerthoffer, JS Kim, EY Ahn, DD Schlaepfer and ST Lim (2019). Nuclear focal adhesion kinase controls vascular smooth muscle cell proliferation and neointimal hyperplasia through GATA4-mediated cyclin D1 transcription. Circulation Research 125(2):152-166. PMID: 31096851

X Feng, N Arang, DC Rigiracciolo, JS Lee, H Yeerna, Z Wang, S Lubrano, A Kishore, JA Pachter, GM Konig, M Maggiolini, E Kostenis, DD Schlaepfer, P Tamayo, Q Chen, E Ruppin and JS Gutkind (2019). A Platform of Synthetic Lethal Gene Interaction Networks Reveals that the GNAQ Uveal Melanoma Oncogene Controls the Hippo Pathway through FAK. Cancer Cell 35: 3457-472. PMID: 30773340

2018

KN Taylor and DD Schlaepfer (2018). Adaptive Resistance to Chemotherapy, A Multi-FAK-torial linkage. Molecular Cancer Therapeutics Apr;17(4):719-723. PMCID: PMC6538033

2017

JR Delaney, CB Patel, KM Willis, M Haghighiabyaneh, J Axelrod, I Tancioni, D Lu, J Bapat, S Young, O Cadassou, A Bartakova, P Sheth, C Haft, S Hui, C Saenz, DD Schlaepfer, O Harismendy and DG Stupack (2017). Haploinsufficiency networks identify targetable pattern of allelic deficiency in low mutation ovarian cancer. Nature Communications 8:14423. PMID: 28198375

EG Kleinschmidt and DD Schlaepfer (2017). Focal adhesion kinase signaling in unexpected places. Current Opinion in Cell Biology 45: 24-30. PMID: 28213315

2016

A Yurdagul Jr, FJ Sulzmaier, XL Chen, CB Pattillo, DD Schlaepfer and AW Orr (2016). Oxidized LDL induces FAK-dependent RSK signaling to drive NF-κB activation and VCAM-1 expression. Journal of Cell Science 129, 1580-1591. PMID: 26906414

H Laklai, YA Miroshnikova, MW Pickup, EA Collisson, GE Kim, AS Barrett, RC Hill, JN Lakins, DD Schlaepfer, JK Mouw, VS LeBleu, N Roy, SV Novitsky, JS Johansen, V Poli, R Kalluri, CA Iacobuzio-Donahue, LD Wood, M Hebrok, K Hansen, HL Moses and VM Weaver (2016). Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression. Nature Medicine 5: 497-505. PMID: 27089513

2015

I Tancioni, NLG Miller, S Uryu, C Lawson, C Jean, XL Chen, EG Kleinschmidt and DD Schlaepfer (2015). FAK activity protects nucleostemin in facilitating breast cancer spheroid and tumor growth. Breast Cancer Research 17:47 PMCID: PMC4407832

M. Masià-Balague, I Izquierdo, G Garrido, A Cordomí, L Perez, NLG Miller, DD Schlaepfer, V Gigoux and AM Aragay (2015). Gastrin-stimulated Galpha13 activation of Rgnef (ArhGEF28) in DLD-1 colon carcinoma cells. Journal of Biological Chemistry 290:15197-209. PMCID: PMC4463461

SA Young, KE McCabe, A Bartakova, JR Delaney, DP Pizzo, RO Newbury, JA Varner, DD Schlaepfer and DG Stupack (2015). Integrin α4 enhances metastasis and may be associated with poor prognosis in MYCN-low neuroblastoma. PLoS ONE 10(5): e0120815. PMCID: PMC4431816

C Gao, G Chen, SH Kuan, DH Zhang, DD Schlaepfer and J Hu (2015). FAK/PYK2 promotes the Wnt/b-catenin pathway and intestinal tumorigenesis by phosphorylating GSK3β. eLife; 10.7554/eLife.10072. PMCID: PMC4558782

JR Delaney, C Patel, KE McCabe, D Lu, MA Davis, I Tancioni, T Khattar, A Bartakova, C Haft, DD Schlaepfer and DG Stupack (2015). A strategy to combine pathway-targeted low toxicity drugs in ovarian cancer. Oncotarget 6: 31104-31118. PMID: 26418751

2014

C Jean, XL Chen, JO Nam, S Uryu, I Tancioni, C Lawson, KK Ward, CT Walsh, NLG Miller, M Ghassemian, P Turowski, E Dejana, DA Cheresh and DD Schlaepfer, DD (2014). Inhibition of endothelial FAK activity prevents tumor metastasis by enhancing barrier function. Journal of Cell Biology 204: 247-263. PMCID: PMC3897185

I Tancioni, S Uryu, FJ Sulzmaier, NR Shah, C Lawson, NLG Miller, C Jean, XL Chen, KK Ward and DD Schlaepfer (2014). FAK inhibition disrupts a β5 integrin signaling axis controlling anchorage-independent ovarian carcinoma growth. Molecular Cancer Therapeutics 13: 2050-61. PMCID: PMC4126870

NR Shah, I Tancioni, KK Ward, C Lawson, XL Chen, C Jean, FJ Sulzmaier, S Uryu, NLG Miller, DC Connolly and DD Schlaepfer (2014). Analyses of merlin/NF2 connection to FAK inhibitor responsiveness in serous ovarian cancer. Gynecologic Oncology 134: 104-11 PMCID: PMC4065804

NLG Miller, EG Klenischmidt and DD Schlaepfer (2014). RhoGEFs in cell motility: Novel links between Rgnef and focal adhesion kinase. Current Molecular Medicine 2: 221-234. PMCID: PMC4075329

FJ Sulzmaier, C Jean and DD Schlaepfer (2014). FAK in cancer: mechanistic findings and clinical applications. Nature Reviews Cancer 14: 598-610. PMCID: PMC4365862

SY Cheng, G Sun, DD Schlaepfer and CJ Pallen (2014). Grb2 promotes integrin-induced focal adhesion kinase (FAK) autophosphorylation and directs the phosphorylation of protein tyrosine phosphatase α by the Src-FAK kinase complex. Molecular and Cellular Biology 34: 348-61. PMCID: PMC3911518

2013

KK Ward, I Tancioni, C Lawson, NLG Miller, C Jean, XL Chen, S Uryu, J Kim, DG Stupack, SC Plaxe and DD Schlaepfer (2013). Inhibition of focal adhesion kinase (FAK) activity prevents anchorage-independent ovarian carcinoma cell growth and tumor progression. Clinical and Experimental Metastasis 5: 579-94. PMCID: PMC3622195

R Graf, S Barbero, N Keller, XL Chen, S Uryu, DD Schlaepfer and DG Stupack, DG (2013). Src inducible association of CrkL with procaspase-8 promotes cell migration. Cell Adhesion and Migration 7: 362-369. PMCID: PMC3739813

NLG Miller, C Lawson, S Uryu, EG Klenischmidt and DD Schlaepfer, DD (2013). A non-canonical role for Rgnef in promoting integrin-stimulated focal adhesion kinase activation. Journal of Cell Science 126: 5074–5085. PMCID: PMC3820247

C Lawson and DD Schlaepfer (2013). pHocal adhesion kinase regulation is on a FERM foundation. Journal of Cell Biology 202: 833-836. PMCID: PMC3776349

2012

XL Chen, JO Nam, C Jean, C Lawson, CT Walsh, E Goka, ST Lim, A Tomar, I Tanjoni, S Uryu, JL Guan, LM Acevedo, SM Weis, DA Cheresh, and DD Schlaepfer (2012). VEGF-induced vascular permeability is mediated by FAK. Developmental Cell 22: 146-157. PMCID: PMC3266538

M Huang, S Anand, EA Murphy, JS Desgrosellier, DG Stupack, SJ Shattil, DD Schlaepfer, DD and DA Cheresh (2012). EGFR-dependent pancreatic carcinoma cell metastasis through Rap1 activation. Oncogene 31: 2783-2793. PMCID: PMC3711644

C Lawson, ST Lim, S Uryu, XL Chen, DA Calderwood and DD Schlaepfer, DD (2012). FAK promotes recruitment of talin to nascent adhesions to control cell motility. Journal of Cell Biology 196: 223-232. PMCID: PMC3265949

SK Lau, DJ Shields, EA Murphy, JS Desgrosellier, S Anad, M Huang, ST Lim, DD Schlaepfer and DA Cheresh (2012). EGFR-mediated carcinoma cell metastasis mediated by integrin avb5 depends on activation of c-Src and cleavage of MUC1. PLosOne 7(5): e36753. PMCID: PMC3346745

NLG Miller, C Lawson, XL Chen, ST Lim and DD Schlaepfer (2012). Rgnef (p190RhoGEF) knockout inhibits RhoA activity, focal adhesion establishment, and cell migration downstream of integrins PLosOne 7(5): e36753. PMCID: PMC3359313

ST Lim, NLG Miller, XL Chen, I Tancioni, CT Walsh, C Lawson, S Uryu, SM Weis, DA Cheresh and DD Schlaepfer (2012). Nuclear-localized focal adhesion kinase regulates inflammatory VCAM-1 expression. Journal of Cell Biology 197: 907-919. PMCID: PMC3384409

A Tomar, C Lawson, M Ghassemian and DD Schlaepfer (2012). Cortactin as a target for FAK in the regulation of focal adhesion dynamics. PLosOne 7: e44041. PMCID: PMC3430618

O Jung, S Choi, SB Jang, SA Lee, ST Lim, YJ Choi, HJ Kim, DH Kim, TK Kwak, H Kim, M Kang, MS Lee, SY Park, J Ryu, D Jeong, HK Cheong, HJ Kim, KH Park, BJ Lee, DD Schlaepfer and JW Lee (2012). Tetraspanan TM4SF5-dependent direct activation of FAK and metastatic potential of hepatocarcinoma cells. Journal of Cell Science 125: 5960-73. PMCID: PMC4074290

C Lawson and DD Schlaepfer (2012). Integrin adhesions: Who's on first? What's on second? Connections between FAK and talin. Cell Adhesion & Migration 6: 302-306. PMCID: PMC3478250

2011

HG Yu, JO Nam, NLG Miller, I Tanjoni, CT Walsh, L Shi, L Kim, XL Chen, A Tomar, ST Lim and DD Schlaepfer (2011). p190RhoGEF (Rgnef) promotes colon carcinoma tumor progression via interaction with focal adhesion kinase. Cancer Research 71: 360-70. PMCID: PMC3064514

J Seong, M Ouyang, T Kim, J Sun, PC Wen, S Lu, Y Zhuo, NM Llewellyn, DD Schlaepfer, JL Guan, S Chien and Y Wang (2011). Detection of focal adhesion kinase activation at membrane microdomains by fluorescence resonance energy transfer. Nature Communications 2: 406. PMCID: PMC3373894

XY Li, X Zhou, RG Rowe, Y Hu, DD Schlaepfer, D Ilic, G Dressler, A Park, JL Guan and SJ Weiss (2011). Snail1 controls epithelial-mesenchymal lineage commitment in focal adhesion kinase-null embryonic cells. Journal of Cell Biology 195: 729-38. PMCID: PMC3257570

2010

ST Lim, NLG Miller, JO Nam, XL Chen, Y Lim and DD Schlaepfer (2010). Pyk2 inhibition of p53 as an adaptive and intrinsic switch promoting cell proliferation and survival. Journal of Biological Chemistry 285: 1743-1753. PMCID: PMC2804332

I Tanjoni, CT Walsh, S Uryu, A Tomar, JO Nam, A Mielgo, ST Lim, C Liang, M Koenig, N Patel, C Kwok, G McMahon, DG Stupack and DD Schlaepfer (2010). PND-1186 FAK inhibitor selectively promotes tumor cell apoptosis in three-dimensional environments. Cancer Biology and Therapy 9: 764-777. PMCID: PMC2933317

CT Walsh, I Tanjoni, S Uryu, A Tomar, JO Nam, H Luo, A Phillips, N Patel, C Kwok, G McMahon, DG Stupack, and DD Schlaepfer (2010). Oral delivery of PND-1186 FAK inhibitor decreases tumor growth and spontaneous breast to lung metastasis in pre-clinical tumor models. Cancer Biology and Therapy 9: 778-790. PMCID: PMC2933309

AM Pasapera, I Schneider, E Rericha, DD Schlaepfer and Waterman (2010). Myosin II activity regulates vinculin recruitment to focal adhesions through FAK-mediated paxillin phosphorylation. Journal of Cell Biology 188: 877-890. PMCID: PMC2845065

ST Lim, XL Chen, A Tomar, NLG Miller, J Yoo and DD Schlaepfer (2010). Knockin mutation reveals an essential role for FAK activity in blood vessel morphogenesis, cell motility-polarity, but not cell proliferation. Journal of Biological Chemistry 285: 21526-21536. PMCID: PMC2898428

A Tomar and DD Schlaepfer (2010). A PAK-Activated Linker for EGFR and FAK. Developmental Cell 18: 170-172. PMCID: PMC3081666

2009

J Ricono, M Huang, L Barnes, S Lau, SM Weis, DD Schlaepfer, SK Hanks and DA Cheresh (2009) Specific crosstalk between EGFR and integrin avb5 promotes carcinoma cell invasion and metastasis. Cancer Research 69: 1383-1391. PMCID: PMC2741736

J Vomaske, RM Melnychuk, PP Smith, J Powell, L Hall, V Defilippis, K Früh, M Smit, DD Schlaepfer, JA Nelson and DN Streblow (2009). Differential ligand binding to a human cytomegalovirus chemokine receptor determines cell type-specific motility. PLoS Pathogen 5: e1000304. PMCID: PMC2637432

S Barbero, A Mielgo, V Torres,T Teitz, DJ Shields, D Mikolon, M Bogoyo, D Barila, JM Lahti, DD Schlaepfer and DG Stupack (2009). Caspase 8 promotes metastasis. Cancer Research. 69: 3755-3763. PMCID: PMC2684981

A Tomar, ST Lim, Y Lim and DD Schlaepfer D.D. (2009). A FAK, p120RasGAP, and p190RhoGAP complex regulates polarity in migrating cells. Journal of Cell Science 122: 1852-1862. PMCID: PMC2684836

A Tomar and DD Schlaepfer (2009). Focal adhesion kinase: Switching between GAPs and GEFs in the control of cell motility. Current Opinion in Cell Biology 21: 673-683. PMCID: PMC2754589

2008

ST Lim, XL Chen DA Hanson, Y Lim, TT Vo, K Howerton, P Dazin, SJ Fisher, DD Schlaepfer* and D Ilic (2008). Nuclear FAK promotes cell proliferation and survival through FERM-enhanced p53 degradation. Molecular Cell, 29: 9-22. PMCID: PMC2234035 *Corresponding author.

Lim, Y., Lim, S.-T., Tomar, A., Gardel, M., Bernard-Trifilo, J.A., Chen, X.L., Uryu, S., Canete-Soler, R., Zhai, J., Lin, H., Schlaepfer, W.W., Nalbant, P., Bokoch, G.M., Ilic, D., Waterman-Storer, C., and Schlaepfer, D.D. (2008). Pyk2 and FAK connections to p190RhoGEF regulate RhoA activity, focal adhesion formation, and cell motility. Journal of Cell Biology 180: 187-203. PMCID: PMC2213606

SM Weis, ST Lim, KM Lutu-Fuga, L Barnes, XL Chen, JR Göthert, TL Shen, JL Guan, DD Schlaepfer and DA Cheresh (2008). Compensatory role for Pyk2 during angiogenesis in adult mice lacking endothelial cell FAK. Journal of Cell Biology 181: 43-50. PMCID: PMC2287283

V Ossovskaya, ST Lim, N Ota, DD Schlaepfer and D Ilic (2008). FAK nuclear export signals sequences. FEBS Letters 582: 2402-6. PMCID: PMC2547126

K Howerton, DD Schlaepfer and D Ilic (2008). Establishment of cell lines from mouse embryos with early embryonic lethality. Cell Communication and Adhesion 15: 379-383. PMCID: PMC3057554

ST Lim, D Mikolon, DG Stupack and DD Schlaepfer (2008). FERM control of FAK function: Implications for cancer therapy. Cell Cycle 7: 2306-2314. PMCID: PMC2574722

L Wu, JA Bernard-Trifilo, Y Lim, ST Lim, SK Mitra, S Uryu, M Chen, CJ Pallen, NKV Cheung, D Mikolon, A Mielgo, DG Stupack and DD Schlaepfer (2008). Distinct FAK-Src activation events promote a5b1- and a4b1-stimulated neuroblastoma cell motility. Oncogene 27: 1439-1448. PMCID: PMC2593630

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